glp-1 and gip dual agonist GIPR/GLP-1R therapies for diabetes weight loss—chemistry, physiology, and clinical applications The dual agonist action of

These findings underscore the multifaceted nature of GLP-1 receptor agonists in cardiovascular risk reduction and have profound implications for the treatment of different profiles of T2D patients

This tachyphylaxis occurs with continuous infusion of GLP-1 (154, 157), long acting GLP-1RAs (156), or tirzepatide (151)

10.1056/NEJMoa2401943

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As a result, drugs such as semaglutide and liraglutide became valuable tools not only for glycemic management but also for cardiovascular risk reduction