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Two recent studies provide important insights into the role of the vagus nerve and cholinergic signaling in pancreatic exocrine cancer

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Previous studies demonstrated that the proliferative and antiapoptotic efficacy of GLP-1RAs, in particular of exendin-4, is mediated by the increased expression of IRS-2 as well as the activation of Akt, key downstream effectors of both insulin (IR) and IGF-1 receptor (IGF-1R) signaling (38)

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