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The company advises against use for: Individuals under 18 years of age Pregnant or breastfeeding women People with pre-existing medical conditions who have not consulted a healthcare professional Some customer complaints arise from individuals who purchased the supplement without realizing these restrictions, only to find that it was not suitable for their situation

doi: 10.1007/s40263-018-0593-6 [DOI] [PubMed] [Google Scholar] 117

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An elevated resting heart rate can increase long-term cardiovascular risk, and regulators need robust data confirming that the metabolic benefits outweigh this potential downside