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GLP-1 based protocols (including semaglutide and tirzepatide) can reduce appetite and improve metabolic markers, but require clinician oversight and follow-up to reduce risks and rebound

GLP-1 Medications May Reduce Pain and Fatigue in Patients with Fibromyalgia A large study suggests that GLP-1 medications may reduce pain, fatigue and the need for opioids in people with fibromyalgia

10.1158/1078-0432.Ccr-11-2994 79 SayemA.AryaA.KarimianH.KrishnasamyN.Ashok HasamnisA.HossainC

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Short-acting agents may have more persistent meal-to-meal gastric-emptying effects, while long-acting agents may show attenuation of this effect over time
