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Furthermore, small molecule inhibitors of GDF8/Activin (KER-065) and antibodies of its receptor ActRII (Bimagrumab) have shown promising results in promoting weight loss while preserving muscle mass in both animal models and clinical trials (Heymsfield et al

doi: 10.2337/db22-338-OR

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This has led to their licensed use for weight management in individuals with obesity or those who are overweight with weight-related comorbidities