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A cluster of residues, including R190 2.60b , N240 3.43b , H363 6.52b , and Q394 7.49b , when mutated, was shown to change the signaling profile of the receptor for cAMP, pERK, and iCa 2+ in both a residue-specific and ligand-specific manner (Wootten et al., 2013c)

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If patients do not achieve the desired standard after 3 months of duplex treatment, triple therapy (i.e., the addition of a glucose-lowering drug with a different mechanism to duplex treatment) should be initiated

Induced by exercise and cold exposure, METRNL promotes beige adipocyte formation and enhances glucose tolerance through immune-mediated mechanisms (Rao et al., 2014)