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In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo

PMID: 41931082, PMCID: PMC13221856, DOI: 10.1016/j.jacadv.2026.102713.Peer-Reviewed Original ResearchAltmetricConceptsObesity medicationsDuke Clinical Research InstituteBody mass indexObesity measuresOM usePlacebo-controlled trialAnti-obesity pharmacotherapyObesity-related complicationsClinical Research InstituteEvidence-basedExpert panelMass indexDysfunctional adiposityObesity researchClinical trial designObesity pharmacotherapyObesityAction itemsOM developmentEthics of placebo-controlled trialsTrial designStreamlining researchPharmacotherapyAnti-obesityCare Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms McKee S, Lydecker J, Pittman B, Jastreboff A , DiLeone R, Lavery M, Grilo C

Appetite reduction and more efficient energy use due to activation of three hormone receptors: GLP-1, GIP, and glucagon receptors

Filtered the solid, washed with MTBE and dried to get the title compound

Specifically, the system Xc transporter, particularly the SLC7A11 subunit, facilitates the uptake of extracellular cystine, a rate-limiting precursor for GSH synthesis (219)