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Second, it limits excess glucose production in the liver by suppressing glucagon release

By interacting with the ECS, particularly through the CB2 receptors, THCV might help in regulating blood sugar levels and reducing insulin resistance

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Sitagliptin is not extensively bound to plasma proteins

Baseline CV comorbidities were assessed using data from any time before the index date, whereas non-CV comorbidities, medication use and disease severity scores (QuanCharlson Comorbidity Index and adapted Diabetes Complications Severity Index [aDCSI]) were assessed in the 12-month baseline period
