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The injection of rAAV-lep increases hypothalamic leptin expression and moderates diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance (Buettner et al., The therapeutic effects of central leptin gene therapy have been reported in insulin-deficient diabetes and in obesity animal models, such as ob/ob, diet-induced obese mice, insulin-deficient type 1 diabetes mice, and insulin-dependent diabetes animals (Akita mice) (Dube et al., 2004, 2006

As noted above tracer studies in humans show that metformin lowers hepatic glucose production and increases hepatic insulin sensitivity (48)

Blitz goes on to say that These formulations may mislead patients into believing they are receiving a superior or customized product, when in reality, they are being exposed to unvalidated risks without a clear medical benefit. Other Medical Experts Weigh in on Compounded GLP-1 Safety When asked about compounded GLP-1s, Megahan Garcia-Webb, MD, a triple board-certified physician specializing in obesity medicine and producer of the YouTube series Weight Medicine with Dr

Correction A correction for this article appears in the September 2023 issue of Medicine Today (see link here)