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GLP-1 indeed stimulates postprandial insulin secretion, inhibits glucagon release, and reduces food intake through the delay of gastric emptying and the suppression of appetite (59)

Kimura Y, Koda T, Kurakami H, Sakamoto S, Iwasaki K, Mochizuki H

Poldermans D, Bax JJ, Boersma E, De Hert S, Eeckhout E, Fowkes G, Gorenek B, Hennerici MG, Iung B, Kelm M, Kjeldsen KP, Kristensen SD, Lopez-Sendon J, Pelosi P, Philippe F, Pierard L, Ponikowski P, Schmid JP, Sellevold OF, Sicari R, Van den Berghe G, Vermassen F

Therefore, a pivotal question is whether the demonstrated BBB permeability of certain GLP-1RAs translates to effective penetration of the BRB to achieve therapeutic concentrations in retinal tissues