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The effective semaglutide dose range in this paradigm (0.010.1 mg/kg for males, 0.03-0.1 mg/kg for females) is consistent with doses reported to reduce alcohol self-administration and intake (0.0003-0.01mg/kg) in rodent and nonhuman primate models (0.003-0.01 mg/kg

In fact, the clinical diagnosis of PD requires the presence of bradykinesia accompanied by at least one other motor symptom, such as resting tremor, muscle rigidity, or postural instability

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Although some studies have demonstrated brain distribution following intranasal delivery for specific peptides, this cannot be generalized to all GLP-1 analogues

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