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For all of the concomitant medications evaluated in this study, the ratio for total exposure (AUC) was within the pre-specified limits (0.801.25), suggesting that there are no drugdrug interactions between semaglutide and the co-administered drugs

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Retatrutide vs Tirzepatide (Mounjaro and Zepbound) Tirzepatide was the first dual agonist to hit the market, combining GLP-1 and GIP