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ROS and the metabolic adaptations which accompany ROS exposure, have now been shown to mediate cellular reprogramming by selecting for aggressive features, such as enhanced invasiveness and resistance to therapy
GoniewiczMLSmithDMEdwardsKCBlountBCCaldwellKLFengJet alComparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

If left unrepaired, the damage can worsen, potentially leading to more extensive repairs down the line
greater increases in both systolic (top number) and diastolic (lower number) blood pressure

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