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Mounjaro (tirzepatide) GLP-1 + GIP In SURMOUNT-1 (72 weeks), average weight loss at the highest dose was often quoted around: ~22.5% (highest dose) What that looks like: If you start at 100 kg , ~22.5% is about 2223 kg lost on average

In patients with type 2 diabetes, treatment with semaglutide 1 mg resulted in reductions in glucose in terms of absolute change from baseline and relative reduction compared to placebo of 29 mg/dL (22%) for fasting glucose, 74 mg/dL (36%) for 2-hour postprandial glucose, and 30 mg/dL (22%) for mean 24-hour glucose concentration (see Figure 1)