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This led to the assumption that the primary receptors mediating weight loss for this target class were AMYRs, yet, dual agonists are reported to have higher efficacy than AMYR selective agonists 2,10,11,12

Lorcaserin (APD356), a selective 5-HT(2C) agonist, reduces body weight in obese men and women

Patients typically receive injections once or twice weekly for the first two weeks, followed by monthly maintenance doses, making the treatment cost-effective for those requiring consistent B12 supplementation

It is not approved by the FDA for human or veterinary use

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