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Whole-genome sequencing of tumor samples requires the analysis of several tens of thousands of distinct single-nucleotide variations, which makes tumor cells a genetic"train wreck"(Lee et al

Piga et al., 2006)

doi: 10.3389/fphys.2023.1114231 Received 05 December 2022 Accepted 29 March 2023 Published 25 April 2023 Volume 14 - 2023 Edited by Carlos Palmeira, University of Coimbra, Portugal Reviewed by Jess Rodrguez Huertas, University of Granada, Spain Ricardo Marques, University of Coimbra, Portugal Heather M

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It has been extensively demonstrated that immune checkpoint inhibitors (ICIs) can result in prolonged remission in certain patients