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Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

Furthermore, the authors indicated that, upon comparison with the literature, the effective concentration was sufficiently low to suggest a signaling role for Epitalon in the cascades of the cellular antioxidant system [57]

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