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Glutathionylation of -ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification

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Miltefosine remains a key option, particularly in areas with limited injectable access, though issues of teratogenicity and resistance drive interest in more accessible oral formulations ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions ( Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)