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While everyone responds, clinical studies and patient stories reveal some common trends

The depth of evidence differs sharply, and findings in one population may not translate to others

Browning of White Adipose Tissue Third, and perhaps most fascinating, NNMT inhibition promotes browning of white adipose tissue - the conversion of white adipocytes into beige/brown adipocytes that contain numerous mitochondria and express uncoupling protein 1 (UCP1), enabling them to dissipate energy as heat through non-shivering thermogenesis

Initial work on this project was funded by a Wellcome Trust Pathfinder Award to W.W.Y

Biochemistry 45 , 79988008 (2006)