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In line, lactate also accumulated to a higher extent in the culture medium of Gclc fl/fl Mb1-Cre + FoB as compared to control cells (Fig

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Conversion is fine for most healthy younger adults, but can be less efficient in people with MTHFR genetic variants (an estimated 25 to 40% of the population carries at least one variant), people with liver function decline (more common with age), and smokers and former smokers