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As with all research compounds, investigators should implement appropriate laboratory safety protocols and follow institutional guidelines for handling investigational chemical compounds in controlled research environments

Additionally, oral supplements require daily adherence to maintain consistent levels, which can be a challenge for some people

Various neurological symptoms with vitamin B12 deficiency and posttreatment evaluation

Concern about excessive intake and potential adverse effects of folic acid in addition to other health outcomes has been the subject of NIH-sponsored workshops and meetings of experts (88, 89)

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