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The mutations in the G6PD gene are deleterious and, thus, theoretically should have been weeded out of the genome, according to the normal way that mutations work in a population

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Eur J Endocrinol 148:309315 Contempre B, Je D, Bebe NGO, CH T, AT D, Vanderpas J (1991) Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area : the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium