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Although our previous preclinical studies suggest that a causal link exists between circulating IGF-1 deficiency and impairment of NVC responses, ascertaining the cause-and-effect relationship between age-related IGF-1 deficiency and impaired functional hyperemia in humans requires additional evidence

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Extrapolating from B12 supplementation trials of non-vegans to determine the needs of vegans is complicated by the fact that a high percentage of any small dose of B12 is absorbed and omnivores are normally receiving numerous small doses throughout the day