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The drug delivery to the brain is characterized by three main neuropharmacokinetic determinants, such as rate of BBB permeation, extent of brain delivery and intra-brain distribution of drug, allowing to assess the brain delivery efficacy of developed transporter-utilizing (pro)drugs or nanocarriers

Not FDA-approved for any therapeutic use

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Additionally, the review highlights the utility of PLGA nanoparticles in delivering phytochemicals with neuroprotective effects such as polyphenols, flavonoids, and coumarins to overcome challenges associated with their solubility and stability and ultimately enhance their activities for managing PD